Lax1^tm1Wz
Targeted Allele Detail

Summary

• Symbol: Lax1^tm1Wz
• Name: lymphocyte transmembrane adaptor 1; targeted mutation 1, Weiguo Zhang
• MGI ID: MGI:3579135
• Synonyms: LAX^-
• Gene: Lax1 Location: Chr1:133606829-133617846 bp, - strand Genetic Position: Chr1, 57.95 cM
• Alliance: Lax1^tm1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98403
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exons 2-4 with a neomycin resistance gene. Exon 2 encodes the transmembrane domain. Western blot analysis failed to detect protein in mutant splenocytes. (J:98403)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lax1 Mutation: 33 strains or lines available

References

• Original: J:98403 Zhu M, et al., Negative regulation of lymphocyte activation by the adaptor protein LAX. J Immunol. 2005 May 1;174(9):5612-9
• All: 1 reference(s)