Park7^tm1Shn
Targeted Allele Detail

Summary

• Symbol: Park7^tm1Shn
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Jie Shen
• MGI ID: MGI:3579140
• Synonyms: DJ-1^-
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1Shn page

Characterization of Park7^tm1Shn/Park7^tm1Shn mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98436
• Parent Cell Line: MKV6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a pgk-neo cassette. Western blot failed to detect protein in mutant mice. (J:98436)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:98436 Goldberg MS, et al., Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron. 2005 Feb 17;45(4):489-96
• All: 63 reference(s)