Tg(Ins2-VEGFC)#Pepr
Transgene Detail

Summary

• Symbol: Tg(Ins2-VEGFC)#Pepr
• Name: transgene insertion, Michael S Pepper
• MGI ID: MGI:3579151
• Synonyms: RIP1VEGF-C, RipVEGF-C
• Transgene: Tg(Ins2-VEGFC)#Pepr Location: unknown
• Alliance: Tg(Ins2-VEGFC)#Pepr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-VEGFC)#Pepr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VEGFC (7424)

  Vegfc

  (MGI:109124)

• Tg(Ins2-VEGFC)#Pepr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The transgene was constructed by cloning the human vascular endothelial growth factor C cDNA between the ~695 bp BamHI-XbaI fragment of Rip (rat insulin II promoter) and the SV40 small T antigen intron and polyadenylation signal. Two founder lines generated: family 23 and family 24. Mice of "family 23" carry one copy of the transgene. Mice of "family 24" carry four to six copies of the transgene. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:67489)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins2-VEGFC)#Pepr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:67489 Mandriota SJ, et al., Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J. 2001 Feb 15;20(4):672-82
• All: 3 reference(s)