Kras^b
Allele Detail

Summary

• Symbol: Kras^b
• Name: Kirsten rat sarcoma viral oncogene homolog; b variant
• MGI ID: MGI:3579273
• Synonyms: 0.70-kB KRAS2 allele, Allele 2, resistant allele
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^b page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable
• Mutation: Undefined
• This variant results in an EcoRI band of 0.7 kb.

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kras^b

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 84 strains or lines available

Notes

The b variant has been observed in the following strains: AKR/J, B10.O20, C58/J, C57BL/6J, C57L/J, C3H/HeJ, OcB6, OcB15 SJL/J and DBA/2J. This variant has been shown to confer resistance to pulmonary tumors.

References

• Original: J:8509 Ryan J, et al., An EcoRI restriction fragment length polymorphism at the KRAS2 locus on mouse chromosome 6. Nucleic Acids Res. 1986 Nov 25;14(22):9222
• All: 3 reference(s)