H2^k
Allele Detail

Summary

• Symbol: H2^k
• Name: histocompatibility-2, MHC; k variant
• MGI ID: MGI:3579322
• Synonyms: H-2^k
• Gene: H2 Location: unknown Genetic Position: Chr17, cytoband B-C

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Not Applicable

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	H2^k/H2^k	NOD.Cg-H2^k
ht2	H2^k/H2^g7	NOD.Cg-H2^k
cx3	H2^b/H2^k Itk^tm1Ljb/Itk^tm1Ljb Tg(TcrAND)53Hed/?	involves: C3H/HeJ * C57BL/6 * C57BL/10
cx4	H2^b/H2^k Tg(TcraTcrb)1100Mjb/?	involves: C57BL/6 * C57BL/10Sg * C57BR/c
cx5	H2^k/H2^k Tg(TcraTcrbAD10)1Hed/?	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	hm1	ht2	cx3	cx4	cx5
show or hide all annotated terms
endocrine/exocrine glands	√			√
small thymus				√
periinsulitis	√
hematopoietic system			√	√	√
small thymus				√
abnormal negative T cell selection				√
abnormal positive T cell selection			√
decreased CD4-positive, alpha-beta T cell number			√
increased CD4-positive, alpha-beta T cell number					√
decreased CD8-positive, alpha-beta T cell number				√
homeostasis/metabolism	√
increased physiological sensitivity to xenobiotic	√
immune system	√	√	√	√	√
small thymus				√
periinsulitis	√
abnormal negative T cell selection				√
abnormal positive T cell selection			√
decreased CD4-positive, alpha-beta T cell number			√
increased CD4-positive, alpha-beta T cell number					√
decreased CD8-positive, alpha-beta T cell number				√
decreased susceptibility to autoimmune diabetes		√
increased susceptibility to autoimmune diabetes	√

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying H2^k

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 14 strains available Cell Lines: 0 lines available
• Carrying any H2 Mutation: 284 strains or lines available

Notes

The k variant has been observed in the following strains: C3H, C3H/HeJ, C3H/An, C3H/Bi, C3H/DiSn, C3H/St, CBA, CBA/CaJ, CBA/N, AKR/J, CE/J, C57BR/cdJ, C58/J, MA/J, RF/J, ST/bJ, MRL/MpJ-Fas^lpr/J

References

• Original: J:7097 Klein J, et al., H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics. 1983;17(6):553-96
• All: 34 reference(s)