Cia39^C57BL/10Sn
QTL Variant Detail

Summary

• QTL variant: Cia39^C57BL/10Sn
• Name: collagen induced arthritis 39; C57BL/10Sn
• MGI ID: MGI:3579358
• QTL: Cia39 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/10Sn

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers collagen induced arthritis resistance compared to RIII/WySn. (J:97801)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele exhibits additive inheritance and shows interaction with the H2 locus on chromosome 17.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:97801

H2 congenic strains B10.RIII/Lund-H2^r and B10.Q/Lund-H2^q are highly susceptible to collagen-induced arthritis (CIA). Congenic B10.RIII/Lund-H2^r is derived from CIA resistant donor strain RIII/WySn-H2^r and CIA susceptible background strain C57BL/10Sn-H2^b. Congenic B10.Q/Lund-H2^q is derived from donor strain DBA/1-H2^q and background strain C57BL/10Sn-H2^b. These 2 congenics should only differ from their background strains at the H2 locus. However, genome scan using 150 microsatellite markersrevealed RIII/WySn contamination on a segment of mouse Chromosome 10 from D10Mit196 (31 cM) to D10Mit178 (59 cM) in the B10.RIII/Lund-H2^r congenic. This locus coincides with Cia8 and is designated Cia39.

A new congenic was created by introgressing an RIII/WySn-derived Cia39 interval onto the genetic background of B10.Q/Lund-H2^q. The reciprocal congenic was also created in which a C57BL/10Sn-derived Cia39 interval from donor strain B10.Q/Lund-H2^q was introgressed onto the genetic background of B10.RIII/Lund-H2^r. As expected, the RIII/WySn-derived Cia39 interval significantly increased CIA incidence and severity on the B10.Q/Lund-H2^q background while the C57BL/10-derived Cia39 interval decreased CIA incidence and severity on the B10.RIII/Lund-H2^r background. This finding suggests that Cia39 in conjunction with the H2 interval on mouse Chromosome 17 influences CIA susceptibility. Cia39 appears to have an additive effect.

Potential candidate genes mapping near Cia39 are Bsg (42.4 cM), Lilrb4(32cM),Ostm1 (29 cM), Prf1 (36 cM), Mif (40.9 cM), Mmp11 (40.9 cM), Aire (41.6 cM), Timp3 (47 cM), Itgb2 (41.5 cM), Igf1 (48 cM), and Socs2 (52 cM).

Previously identified arthritis QTLs mapping near Cia39 are Pgia6 (12 cM), Eae17 (36 cM), Asm1 (39 cM), Lmb4(41 cM),Asthm1 (44 cM), and Bbaa18 (31.5 cM).

Several autoimmune QTLs have been mapped to the H2 locus on mouse Chromosome 17. These QTLs include Cia1, Pgia17, Bbaa8, Eae1, Eae5, Sles1, Asbb3, Mbis4, Orch1, Cdcs5, Ssial4, and Idd1.

References

• Original: J:97801 Nandakumar KS, et al., A genetic contamination in MHC-congenic mouse strains reveals a locus on chromosome 10 that determines autoimmunity and arthritis susceptibility. Eur J Immunol. 2005 Apr;35(4):1275-82
• All: 1 reference(s)