Tg(CAG-Angptl6)8.1Yo
Transgene Detail

Summary

• Symbol: Tg(CAG-Angptl6)8.1Yo
• Name: transgene insertion 8.1, Yuichi Oike
• MGI ID: MGI:3579408
• Synonyms: Tg(Actb-Angpt16)8.1Yo, Tg(CAG-Angpt16)8.1Yo
• Transgene: Tg(CAG-Angptl6)8.1Yo Location: unknown
• Alliance: Tg(CAG-Angptl6)8.1Yo page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:97552
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Angptl6)8.1Yo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Angptl6 (MGI:1917976)

• Mutation details: This transgene consists of the CMV enhancer with the chicken beta-actin promoter, a floxed Blasticidin resistance gene and the Angpt16 gene. Cre mediated recombination removes the Blasticidin resistance gene and allows expression of Angpt16 in brown adipose tissue, heart, and skeletal muscle. Angpt16 concentration increased approximately twofold. Three lines were made. This is a representative record representing lines 8-1, 9-1, and 16-1, all of which have identical phenotypes. (J:97552)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97552 Oike Y, et al., Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med. 2005 Apr;11(4):400-8
• All: 1 reference(s)