Kifap3^tm1.1Noh
Targeted Allele Detail

Summary

• Symbol: Kifap3^tm1.1Noh
• Name: kinesin-associated protein 3; targeted mutation 1.1, Nobutaka Hirokawa
• MGI ID: MGI:3579410
• Synonyms: Kap3^-
• Gene: Kifap3 Location: Chr1:163607152-163744678 bp, + strand Genetic Position: Chr1, 71.08 cM, cytoband H1
• Alliance: Kifap3^tm1.1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98470
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was derived from Kifap3^tm1Noh. Cre recombinase excised exon 3 and produced a frame shift mutation that truncated the protein. Immunoblot of E14.5 brain lysates detected a significant loss of protein. (J:98470)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kifap3 Mutation: 53 strains or lines available

References

• Original: J:98470 Teng J, et al., The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. Nat Cell Biol. 2005 May;7(5):474-82
• All: 1 reference(s)