Fkbp4^tm1Dvds
Targeted Allele Detail

Summary

• Symbol: Fkbp4^tm1Dvds
• Name: FK506 binding protein 4; targeted mutation 1, David F Smith
• MGI ID: MGI:3579432
• Synonyms: 52KO, Fkbp52-
• Gene: Fkbp4 Location: Chr6:128407066-128415619 bp, - strand Genetic Position: Chr6, 63.0 cM
• Alliance: Fkbp4^tm1Dvds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98554
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the entire coding sequence. Western blot failed to detect protein in thymic cytosol of mutants. (J:98554)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fkbp4 Mutation: 32 strains or lines available

References

• Original: J:98554 Cheung-Flynn J, et al., Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol. 2005 Jun;19(6):1654-66
• All: 10 reference(s)