Gabrg2^tm2Geh
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm2Geh
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 2, Gregg E Homanics
• MGI ID: MGI:3579440
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm2Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98560
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A targeting vector was constructed to flank exon 8 with loxP sites. A neomycin selection cassette was placed downstream of exon 8, within the floxed sequence. Gene expression was demonstrated to be highly variable, ranging from 10-95% of normal, with the average reduction being 65%. Immunohistochemical analysis demonstrated that protein levels were variably reduced. (J:98560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:98560 Chandra D, et al., GABAA receptor gamma2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci. 2005 Apr 25;6(1):30
• All: 1 reference(s)