Slc9a4^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Slc9a4^tm1Ges
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4; targeted mutation 1, Gary E Shull
• MGI ID: MGI:3579458
• Synonyms: NHE4^-
• Gene: Slc9a4 Location: Chr1:40619241-40669885 bp, + strand Genetic Position: Chr1, 19.51 cM
• Alliance: Slc9a4^tm1Ges page

Abnormal gastric epithelium in 9 week old Slc9a4^tm1Ges/Slc9a4^tm1Ges mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98566
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert a neomycin resistance into exon 2. Northern blot demonstrated a reduction in the size of the transcript in mutant stomach tissue. Sequence analysis showed that exon 2 and the neo gene had been excised and exon 1 was spliced to exon 3. (J:98566)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc9a4 Mutation: 39 strains or lines available

References

• Original: J:98566 Gawenis LR, et al., Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchanger. J Biol Chem. 2005 Apr 1;280(13):12781-9
• All: 2 reference(s)