Npc1l1^tm1Yaio
Targeted Allele Detail

Summary

• Symbol: Npc1l1^tm1Yaio
• Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Yiannis A Ioannou
• MGI ID: MGI:3579462
• Synonyms: L1KO, NPC1L1^-
• Gene: Npc1l1 Location: Chr11:6161013-6180143 bp, - strand Genetic Position: Chr11, 3.93 cM
• Alliance: Npc1l1^tm1Yaio page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98568
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a PGK-neo cassette into exon 2 at nucleotide 91263 interrupted the gene after cDNA nucleotide 601, thereby abrogating any alternatively spliced gene forms. (J:98568)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npc1l1 Mutation: 48 strains or lines available

Notes

Homologous recombination was carried out using C57BL/6 ES cells obtained from Taconic. (J:98568)

References

• Original: J:98568 Davies JP, et al., Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J Biol Chem. 2005 Apr 1;280(13):12710-20
• All: 13 reference(s)