L3mbtl3^tm1Tmiy
Targeted Allele Detail

Summary

• Symbol: L3mbtl3^tm1Tmiy
• Name: L3MBTL3 histone methyl-lysine binding protein; targeted mutation 1, Toru Miyazaki
• MGI ID: MGI:3579468
• Synonyms: MTB-1^-
• Gene: L3mbtl3 Location: Chr10:26150366-26251967 bp, - strand Genetic Position: Chr10, 13.67 cM
• Alliance: L3mbtl3^tm1Tmiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98498
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 15. Northern blot of mutant liver demonstrated the complete lack of transcript. (J:98498)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any L3mbtl3 Mutation: 52 strains or lines available

References

• Original: J:98498 Arai S, et al., Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. EMBO J. 2005 May 18;24(10):1863-73
• All: 2 reference(s)