Agrn^tm1Rwb
Targeted Allele Detail

Summary

• Symbol: Agrn^tm1Rwb
• Name: agrin; targeted mutation 1, Robert W Burgess
• MGI ID: MGI:3579476
• Synonyms: Agrn^fl
• Gene: Agrn Location: Chr4:156249747-156281945 bp, - strand Genetic Position: Chr4, 88.55 cM
• Alliance: Agrn^tm1Rwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122821
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted into introns 6 and 33. (J:122821)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agrn Mutation: 102 strains or lines available

References

• Original: J:122821 Harvey SJ, et al., Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. Am J Pathol. 2007 Jul;171(1):139-52
• All: 6 reference(s)