Stk11^tm1Keis
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1Keis
• Name: serine/threonine kinase 11; targeted mutation 1, Kei Sakamoto
• MGI ID: MGI:3579498
• Synonyms: LKB1^fl, Lkb1^hypo
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1Keis page

Urothelial hyperplasia and increased apoptosis in bladder epithelium of Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98513
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Stk11^tm1Keis/Stk11^tm1Keis	Not Specified
cn2	Stk11^tm1Keis/Stk11^tm1Keis Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd
cn3  Disease Model	Pten^tm2Mak/Pten^tm2Mak Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
cn4	Stk11^tm1Keis/Stk11^tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
cn5	Stk11^tm1Keis/Stk11^tm1Keis Tg(Ckmm-cre)5Khn/0	involves: FVB
cn6	Stk11^tm1Keis/Stk11^tm1Keis Tg(Pomc1-cre)1Gsb/0	involves: FVB/N

Phenotypes:

Affected Systems	hm1		cn2	cn3	cn4	cn5		cn6
show or hide all annotated terms Sex:
behavior/neurological								√
decreased fluid intake								√
cellular						√	√
decreased muscle cell glucose uptake						√	√
digestive/alimentary system					√
gastric polyps					√
endocrine/exocrine glands								N
endocrine/exocrine gland phenotype								N
growth/size/body	N	N		√		N	N
growth/size/body region phenotype	N	N				N	N
enlarged urinary bladder				√
homeostasis/metabolism	N	N	√					√
homeostasis/metabolism phenotype	N	N						N
increased circulating interleukin-10 level			√
abnormal gluconeogenesis								√
impaired glucose tolerance								√
abnormal glycogen homeostasis								√
insulin resistance								√
immune system			√
increased circulating interleukin-10 level			√
mortality/aging	√	√		√
premature death				√
perinatal lethality, incomplete penetrance	√	√
muscle						√	√
decreased muscle cell glucose uptake						√	√
neoplasm				√
increased urinary bladder carcinoma incidence				√
nervous system								N
nervous system phenotype								N
renal/urinary system				√	N
renal/urinary system phenotype					N
enlarged urinary bladder				√
increased urinary bladder carcinoma incidence				√
abnormal urinary bladder mucosa morphology				√
abnormal urinary bladder urothelium morphology				√
urinary bladder obstruction				√
reproductive system		√					√
male infertility		√					√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn3
urinary bladder cancer IDs urinary bladder cancer       DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk11^tm1Keis

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:98513 Sakamoto K, et al., Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 2005 May 18;24(10):1810-20
• All: 26 reference(s)