Six4^tm1Mair
Targeted Allele Detail

Summary

• Symbol: Six4^tm1Mair
• Name: sine oculis-related homeobox 4; targeted mutation 1, Pascal Maire
• MGI ID: MGI:3579501
• Synonyms: Six1^lacZSix4^gfp, Six1^-Six4^-
• Gene: Six4 Location: Chr12:73146383-73160201 bp, - strand Genetic Position: Chr12, 30.36 cM
• Alliance: Six4^tm1Mair page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98519
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Six1^tm1Mair ES cells were additionally targeted to replace the Six domain and homeodomain, encoded by the last 370 amino acids of exon 1, of Six4 with the EGFP cDNA. (J:98519)

Expression

In Mice Carrying this Mutation:

24 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six4 Mutation: 36 strains or lines available

References

• Original: J:98519 Grifone R, et al., Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
• All: 12 reference(s)