Fdft1^tm1Kan
Targeted Allele Detail

Summary

• Symbol: Fdft1^tm1Kan
• Name: farnesyl diphosphate farnesyl transferase 1; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:3579504
• Synonyms: Fdft1^fl, fdft1^flox, SS^f
• Gene: Fdft1 Location: Chr14:63382599-63417027 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Fdft1^tm1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98525
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: AlLoxP sites were inserted to upstream of exon 5 and A neo cassette and loxP site were inserted downstream of exon 5. (J:98525)

Expression

In Mice Carrying this Mutation:	88 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fdft1 Mutation: 48 strains or lines available

References

• Original: J:98525 Saher G, et al., High cholesterol level is essential for myelin membrane growth. Nat Neurosci. 2005 Apr;8(4):468-75
• All: 9 reference(s)