Itgad^tm1Bll
Targeted Allele Detail

Summary

• Symbol: Itgad^tm1Bll
• Name: integrin, alpha D; targeted mutation 1, Christie M Ballantyne
• MGI ID: MGI:3579559
• Synonyms: CD11d^-
• Gene: Itgad Location: Chr7:127773105-127822988 bp, + strand Genetic Position: Chr7, 70.0 cM
• Alliance: Itgad^tm1Bll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90954
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.2 kb genomic fragment containing exons 1 and 2 were replaced with a neomycin selection cassette. Flow cytometry demonstrated the absence of protein expression in splenocytes. (J:90954)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgad Mutation: 68 strains or lines available

References

• Original: J:90954 Wu H, et al., Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 1;173(1):297-306
• All: 9 reference(s)