Gnas^tm2Kel
Targeted Allele Detail

Summary

• Symbol: Gnas^tm2Kel
• Name: GNAS complex locus; targeted mutation 2, Gavin Kelsey
• MGI ID: MGI:3579575
• Synonyms: Nesp55^-
• Gene: Gnas Location: Chr2:174126113-174188537 bp, + strand Genetic Position: Chr2, 97.89 cM, cytoband E1-H3
• Alliance: Gnas^tm2Kel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97634
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A loxP-flanked cassette containing neo-URA-cre replaced the start codon, disrupting the transcript. (J:97634)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Gnas Mutation: 54 strains or lines available

Notes

ES cell line = IMT11 ("129/SvSLCp").

References

• Original: J:97634 Plagge A, et al., Imprinted Nesp55 influences behavioral reactivity to novel environments. Mol Cell Biol. 2005 Apr;25(8):3019-26
• All: 2 reference(s)