Pcp2^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Pcp2^tm1Bhk
• Name: Purkinje cell protein 2 (L7); targeted mutation 1, Beverly H Koller
• MGI ID: MGI:3579782
• Synonyms: Pcp2^-
• Gene: Pcp2 Location: Chr8:3673371-3675545 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pcp2^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41288
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 445-basepair region including the start sites for transcription and translation are replaced with neo cassette. Western blot confirmed the loss of the Pcp2 protein. (J:41288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcp2 Mutation: 35 strains or lines available

References

• Original: J:41288 Mohn AR, et al., Phenotypic analysis of mice lacking the highly abundant Purkinje cell- and bipolar neuron-specific PCP2 protein. Mol Cell Neurosci. 1997 Jan;9(1):63-76
• All: 3 reference(s)