H1f7^tm1Idvd
Targeted Allele Detail

Summary

• Symbol: H1f7^tm1Idvd
• Name: H1.7 linker histone; targeted mutation 1, Irwin Davidson
• MGI ID: MGI:3579810
• Synonyms: H1t2^-
• Gene: H1f7 Location: Chr15:98153867-98155174 bp, - strand Genetic Position: Chr15, 54.26 cM
• Alliance: H1f7^tm1Idvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96828
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin resistance gene flanked by loxP sites replaced the coding sequence. Immunoblot of mutant testis confirmed absence of protein. (J:96828)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H1f7 Mutation: 20 strains or lines available

References

• Original: J:96828 Martianov I, et al., Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2808-13
• All: 1 reference(s)