Kcp^tm1Gdr
Targeted Allele Detail

Summary

• Symbol: Kcp^tm1Gdr
• Name: kielin/chordin-like protein; targeted mutation 1, Gregory R Dressler
• MGI ID: MGI:3579811
• Synonyms: Kcp^-
• Gene: Kcp Location: Chr6:29473161-29507951 bp, - strand Genetic Position: Chr6, 12.36 cM
• Alliance: Kcp^tm1Gdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97529
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-21, encoding amino acids 67-774, were replaced with a lacZ-neomycin cassette. Absence of transcript in mutants was confirmed by Northern blot and RT-PCR. (J:97529)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcp Mutation: 58 strains or lines available

References

• Original: J:97529 Lin J, et al., Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93
• All: 3 reference(s)