Tbx20^tm1.1Rph
Targeted Allele Detail

Summary

• Symbol: Tbx20^tm1.1Rph
• Name: T-box 20; targeted mutation 1.1, Richard P Harvey
• MGI ID: MGI:3579836
• Synonyms: Tbx20^-, Tbx20^lacZ
• Gene: Tbx20 Location: Chr9:24632108-24685580 bp, - strand Genetic Position: Chr9, 10.25 cM
• Alliance: Tbx20^tm1.1Rph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98489
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination resulted in the excision of the coding sequence in exons 1-3, and the placement of a lacZ reporter gene into endogenous cis-regulatory elements. RT-PCR confirmed absence of exons 1-3 and preservation of exons 4-6. (J:98489)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx20 Mutation: 36 strains or lines available

References

• Original: J:98489 Stennard FA, et al., Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May;132(10):2451-62
• All: 5 reference(s)