Idd16.1^ALR/LtJ
QTL Variant Detail

Summary

• QTL variant: Idd16.1^ALR/LtJ
• Name: insulin dependent diabetes susceptibility 16.1; ALR/LtJ
• MGI ID: MGI:3579888
• QTL: Idd16.1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: ALR/LtJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to type I diabetes mellitus compared to NOD/LtJ. (J:98187)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele confers slower insulitis progression.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98187

Analysis of interval specific congenic lines resolved the Idd16 diabetes QTL into two distinct loci named Idd16a and Idd16b. ALR/LtJ-derived portions of the Idd16 locus were introgressed onto the genetic background of NOD/LtJ. Parental strain ALR/LtJ is resistant to insulin-dependent (type 1) diabetes whereas parental strain NOD/LtJ is susceptible. Three different subcongenic lines were contructed.

Idd16a is localized to the distal portion of the original Idd16 QTL interval between D17Mit13 (19.06 cM) and H2-D (19.09 cM). The ALR/LtJ-derived allele of Idd16a appears to slow insulitis progression, but not its prevention. Potential candidate genes for Idd16a are Tnf (19.06 cM) and H2-D^dx (19 cM). The latter is considered a stronger candidate gene since serum levels of Tnf do not differ between NOD/LtJ and ALR/LtJ. The H2-D^dx allele is thought to be involved in resistance to type 1 diabetes.

Idd16b is localized to the proximal portion of the original Idd16 QTL interval above D17Mit16. Idd16b is involved in resistance to diabetogenesis.

References

• Original: J:98187 Pomerleau DP, et al., Major Histocompatibility Complex-Linked Diabetes Susceptibility in NOD/Lt Mice: Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex. Diabetes. 2005 May;54(5):1603-6
• All: 1 reference(s)