Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
This allele confers slower insulitis progression.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:98187Analysis of interval specific congenic lines resolved the Idd16 diabetes QTL into two distinct loci named Idd16a and Idd16b. ALR/LtJ-derived portions of the Idd16 locus were introgressed onto the genetic background of NOD/LtJ. Parental strain ALR/LtJ is resistant to insulin-dependent (type 1) diabetes whereas parental strain NOD/LtJ is susceptible. Three different subcongenic lines were contructed. Idd16a is localized to the distal portion of the original Idd16 QTL interval between D17Mit13 (19.06 cM) and H2-D (19.09 cM). The ALR/LtJ-derived allele of Idd16a appears to slow insulitis progression, but not its prevention. Potential candidate genes for Idd16a are Tnf (19.06 cM) and H2-Ddx (19 cM). The latter is considered a stronger candidate gene since serum levels of Tnf do not differ between NOD/LtJ and ALR/LtJ. The H2-Ddx allele is thought to be involved in resistance to type 1 diabetes.Idd16b is localized to the proximal portion of the original Idd16 QTL interval above D17Mit16. Idd16b is involved in resistance to diabetogenesis. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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