msrvh1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: msrvh1^C57BL/6
• Name: modifier of susceptibility to renal vascular hypertrophy/hyperplasia 1; C57BL/6
• MGI ID: MGI:3579902
• QTL: msrvh1 Location: Chr3:107376936-115624197 bp Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased incidence and severity of renal vascular lesions compared to 129P2/OlaHsd. (J:87921)

Notes

This allele modifies the effect of Agtr1a^tm1Unc on renal vascular lesions.

Homozygosity for this allele appears to increase the incidence and severity of renal lesions.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87921

Agtr1 null mutant (-/-) mice were obtained from mating 129/J and C57BL/6J Agtr1 mice that were heterozygous for the targeted mutation. The null mutant mice (129/J X C57BL/6J)F1 were backcrossed to C57BL/6J (-/-) for mapping experiments to identify genes from C57BL/6J that modify the Agtr1 phenotype. From the aforementioned cross 119 mice were informative in mapping msrvh1 to mouse Chromosome 3. Locus msrvh1mapped with D3Mit345 (LOD 3.8) and was flanked by D3Mit103 and D3Mit57. At 55 cM msrvh1 maps distal to Agtr1 and therefore is not the same locus. A LRS (likelihood rato statistic) of 17.8 was also observed with D3mit345.

References

• Original: J:87921 Le TH, et al., Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency. Hypertension. 2004 Feb;43(2):445-51
• All: 1 reference(s)