Sycp1^tm1Aps
Targeted Allele Detail

Summary

• Symbol: Sycp1^tm1Aps
• Name: synaptonemal complex protein 1; targeted mutation 1, Albert Pastink
• MGI ID: MGI:3580000
• Synonyms: Sycp1^-
• Gene: Sycp1 Location: Chr3:102725815-102843416 bp, - strand Genetic Position: Chr3, 45.25 cM, cytoband A3
• Alliance: Sycp1^tm1Aps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98718
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 2-8, which contains the splice donor sequence of intron 1, the ATG start codon in exon 2 and about 20% of the ORF. The complete lack of protein was confirmed by Western blot of tetstis cell extracts from mutant mice. (J:98718)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sycp1 Mutation: 57 strains or lines available

References

• Original: J:98718 de Vries FA, et al., Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes Dev. 2005 Jun 1;19(11):1376-89
• All: 17 reference(s)