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Arhgap6/Hccs/Mid1tm1Hzo
Targeted Allele Detail
Summary
Symbol: Arhgap6/Hccs/Mid1tm1Hzo
Name: Rho GTPase activating protein 6; targeted mutation 1, Huda Y Zoghbi
MGI ID: MGI:3580071
Synonyms: MLS2loxP
Gene: Arhgap6  Location: ChrX:167578095-168087431 bp, + strand  Genetic Position: ChrX, 78.77 cM
Alliance: Arhgap6/Hccs/Mid1tm1Hzo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80528
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe gene was replaced by a puromycin resistance gene and a loxP site in ES cells in which Arhgap6 had already been subjected to targeted mutation to replace exons 6, 7, and 8 with a neomycin resistance cassette and a loxP site. The two loxP sites are situated so that cre excision eliminates both resistance genes and all intervening DNA. All of Mid1, the entire Hccs gene, and all of Arhgap6 3' of exon 5 are thus conditionally deleted. (J:80528)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arhgap6 Mutation:  9 strains or lines available
References
Original:  J:80528 Prakash SK, et al., Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant micro-phthalmia with linear skin defects (MLS) syndrome. Hum Mol Genet. 2002 Dec 1;11(25):3237-48
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory