Arhgap6/Hccs/Mid1tm1Hzo
Targeted Allele Detail
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Symbol: |
Arhgap6/Hccs/Mid1tm1Hzo |
Name: |
Rho GTPase activating protein 6; targeted mutation 1, Huda Y Zoghbi |
MGI ID: |
MGI:3580071 |
Synonyms: |
MLS2loxP |
Gene: |
Arhgap6 Location: ChrX:167578095-168087431 bp, + strand Genetic Position: ChrX, 78.77 cM
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Alliance: |
Arhgap6/Hccs/Mid1tm1Hzo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:80528
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The gene was replaced by a puromycin resistance gene and a loxP site in ES cells in which Arhgap6 had already been subjected to targeted mutation to replace exons 6, 7, and 8 with a neomycin resistance cassette and a loxP site. The two loxP sites are situated so that cre excision eliminates both resistance genes and all intervening DNA. All of Mid1, the entire Hccs gene, and all of Arhgap6 3' of exon 5 are thus conditionally deleted.
(J:80528)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Arhgap6 Mutation: |
9 strains or lines available
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Original: |
J:80528 Prakash SK, et al., Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant micro-phthalmia with linear skin defects (MLS) syndrome. Hum Mol Genet. 2002 Dec 1;11(25):3237-48 |
All: |
1 reference(s) |
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