Prkar1a^tm1.1Lsk
Targeted Allele Detail

Summary

• Symbol: Prkar1a^tm1.1Lsk
• Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1.1, Lawrence S Kirschner
• MGI ID: MGI:3580100
• Synonyms: Prkar1a^-, Prkar1a^delta2
• Gene: Prkar1a Location: Chr11:109540231-109560482 bp, + strand Genetic Position: Chr11, 72.33 cM
• Alliance: Prkar1a^tm1.1Lsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98799
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted between exons 1b and 1c and a floxed neomycin resistance cassette was inserted in intron 2. Mice carrying the floxed neomycin resistance cassette were bred to EIIa-cre mice, resulting in removal of the sequences located between exons 1b and 1c and in intron 2. Western blot showed complete absence of protein in mutant mice. (J:98799)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prkar1a^tm1.1Lsk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkar1a Mutation: 19 strains or lines available

References

• Original: J:98799 Kirschner LS, et al., A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res. 2005 Jun 1;65(11):4506-14
• All: 18 reference(s)