Pparg^tm1Lja
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1Lja
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, J Larry Jameson
• MGI ID: MGI:3580102
• Synonyms: PPARKI
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1Lja page

Embryonic lethality of Pparg^tm1Lja/Pparg^tm1Lja mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98786
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The leucine residue at codon 466 was changed to alanine due to a CCT to AGC substitution. RT-PCR confirmed equivalent expression of mutant and wild-type alleles. (J:98786)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:98786 Freedman BD, et al., A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome. J Biol Chem. 2005 Apr 29;280(17):17118-25
• All: 1 reference(s)