Pbw3^DBA/1J
QTL Variant Detail

Summary

• QTL variant: Pbw3^DBA/1J
• Name: pentobarbital withdrawal QTL 3; DBA/1J
• MGI ID: MGI:3580126
• QTL: Pbw3 Location: Chr11:35578616-44065931 bp Genetic Position: Chr11, cM position of peak correlated region/allele: 15.63 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/1J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased pentobarbital withdrawal severity compared to DBA/2J. (J:98588)
• Inheritance: Recessive

Notes

This allele appears to exhibit additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71080

Epistatic QTL pairs associated with pentobarbital withdrawal were screened in 25 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains and confirmed in 404 (C57BL/6J x DBA/2J)F2 intercross animals. Parental strain DBA/2J exhibits severe pentobarbital withdrawal whereas parental strain C57BL/6J exhibits mild pentobarbital withdrawal. A QTL on mouse Chromosome 11, Pbw3 (pentobarbital withdrawal 3), was identfied with a modifier locus, Pbwm (pentobarbital withdrawal modifer), on distal mouse Chromosome 1 in both the BXD RI strains and F2 intercross (P = 0.0006). Pbw3 is linked to D11Ncvs69 and D11Mit82 and spans 14 cM - 16 cM on mouse Chromosome 11. Pbwm, the modifying locus on mouse Chromosome 1 is linked to D1Ncvs80 and D1Mit206 and spans 95 cM - 102 cM. Animals homozygous for C57BL/6J-derived alleles at Pbw3 and homozygous for DBA/2J-derived alleles at Pbwm exhibit the highest pentobarbital withdrawal.

References

• Original: J:98588 Hood HM, et al., Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006 Feb;5(1):1-10
• All: 1 reference(s)