Tg(Pcp2-tTA)3Horr
Transgene Detail

Summary

• Symbol: Tg(Pcp2-tTA)3Horr
• Name: transgene insertion 3, Harry T Orr
• MGI ID: MGI:3580157
• Transgene: Tg(Pcp2-tTA)3Horr Location: unknown
• Alliance: Tg(Pcp2-tTA)3Horr page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene expresses the tetracycline transactivator (tTA) under control of the 5' sequences, including the first exon, the first intron and part of the second exon, of the Purkinje-cell specific mouse Purkinje cell protein 2 gene. (J:95453)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgene mRNA levels in cerebella of mice of nine independent transgenic lines were assayed by Northern blot analysis of cerebellar extracts. The highest-expressing line was selected to cross with mice bearing a TetO-driven transgene.

References

• Original: J:95453 Zu T, et al., Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice. J Neurosci. 2004 Oct 6;24(40):8853-61
• All: 15 reference(s)