Wdr55^tm1Matn
Targeted Allele Detail

Summary

• Symbol: Wdr55^tm1Matn
• Name: WD repeat domain 55; targeted mutation 1, Angabin Matin
• MGI ID: MGI:3580272
• Gene: Wdr55 Location: Chr18:36893275-36896761 bp, + strand Genetic Position: Chr18, 19.46 cM, cytoband B3
• Alliance: Wdr55^tm1Matn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98580
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Targeting took place in ES cells carrying the cre transgene Tg(Prm-cre)70Og, which expresses Cre recombinase under control of the male-germline specific protamine promoter. The insertion of a floxed neo cassette replaced the 3.7 kb coding region. Cre-mediated excision removed the neo cassette upon transmission from male chimeras. (J:98580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr55 Mutation: 18 strains or lines available

References

• Original: J:98580 Youngren KK, et al., The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature. 2005 May 19;435(7040):360-4
• All: 1 reference(s)