Grm6^nob4
Chemically induced Allele Detail

Summary

• Symbol: Grm6^nob4
• Name: glutamate receptor, metabotropic 6; no b wave 4
• MGI ID: MGI:3580353
• Synonyms: negative ERG 1, nerg1, nob2
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^nob4 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutation was identified in an ENU mutagenesis screen at the Center for Functional Genomics (CFG), Northwestern University. A T-to-C transition mutation (nt 709) at codon 185 is predicted to result in a serine to proline substitution that is likely to disrupt the secondary structure of the encoded protein. mRNA expression levels in mutant retina was shown to be approximately 60% of that in control retinas. Immunohistochemistry experiments on mutant retinas failed to detect Grm6 protein that was evident on control retinas. (J:130596)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 53 strains or lines available

Notes

This mutation was briefly named nerg1, negative ERG 1, and renamed to nob2, no b wave 2. Due to a conflicting name with another mutation, this allele was renamed to nob4, no b wave 4.

Electroretinograms (ERGs) of 12 week old mice lack the rod b-wave and scotopic threshold response (STR), whereas the cone electroretinogram is of large amplitude.

References

• Original: J:98867 Center for Functional Genomics (CFG) at Northwestern University, Heritable mouse mutants from Neurogenomics Project at Northwestern University. MGI Direct Data Submission. 2005-6
• All: 7 reference(s)