Mn1^tm1Ecz
Targeted Allele Detail

Summary

• Symbol: Mn1^tm1Ecz
• Name: meningioma 1; targeted mutation 1, Ellen C Zwarthoff
• MGI ID: MGI:3580381
• Synonyms: Mn1^-
• Gene: Mn1 Location: Chr5:111565228-111604899 bp, + strand Genetic Position: Chr5, 53.86 cM
• Alliance: Mn1^tm1Ecz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98889
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin resistance gene into the first exon resulted in the generation of a truncated protein of 121 amino acids, missing less over 90% the protein including the transcription activating domain and the glutamine stretch. (J:98889)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mn1 Mutation: 37 strains or lines available

References

• Original: J:98889 Meester-Smoor MA, et al., Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton. Mol Cell Biol. 2005 May;25(10):4229-36
• All: 3 reference(s)