Frs2^tm3Scl
Targeted Allele Detail

Summary

• Symbol: Frs2^tm3Scl
• Name: fibroblast growth factor receptor substrate 2; targeted mutation 3, J Schlessinger
• MGI ID: MGI:3580390
• Synonyms: Frs2a^-
• Gene: Frs2 Location: Chr10:116905332-116984439 bp, - strand Genetic Position: Chr10, 65.09 cM
• Alliance: Frs2^tm3Scl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98901
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed such that a 0.5 kb fragment containing sequence encoding the first 22 amino acids, the first coding exon, was replaced by an IRES Beta-galactosidase neomycin resistance cassette. (J:98901)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frs2 Mutation: 63 strains or lines available

References

• Original: J:98901 Hadari YR, et al., Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8578-83
• All: 3 reference(s)