Chrm1^tm1Kano
Targeted Allele Detail

Summary

• Symbol: Chrm1^tm1Kano
• Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 1, Masanobu Kano
• MGI ID: MGI:3580391
• Synonyms: M1^-
• Gene: Chrm1 Location: Chr19:8641369-8660970 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Chrm1^tm1Kano page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98902
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo selection cassette replaced a fragment containing the 5' flanking sequence and initiation codon. (J:98902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm1 Mutation: 27 strains or lines available

References

• Original: J:98902 Ohno-Shosaku T, et al., Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus. Eur J Neurosci. 2003 Jul;18(1):109-16
• All: 15 reference(s)