Axin1^tm2Cos
Targeted Allele Detail

Summary

• Symbol: Axin1^tm2Cos
• Name: axin 1; targeted mutation 2, Frank Costantini
• MGI ID: MGI:3580423
• Synonyms: Axin^Ax
• Gene: Axin1 Location: Chr17:26357662-26414785 bp, + strand Genetic Position: Chr17, 13.07 cM
• Alliance: Axin1^tm2Cos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98893
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Axin1^tm2Cos expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Axin1 (MGI:1096327)

• Mutation details: The coding sequence in exon 2 encoding the essential RGS domain was replaced by myc-tagged Axin1 cDNA. This cDNA sequence is for isoform 1, which is 36 amino acids shorter than isoform 2. The mutant protein was expressed at the same level as wild-type. (J:98893)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin1 Mutation: 44 strains or lines available

References

• Original: J:98893 Chia IV, et al., Mouse axin and axin2/conductin proteins are functionally equivalent in vivo. Mol Cell Biol. 2005 Jun;25(11):4371-6
• All: 3 reference(s)