Crocc^tm1Tili
Targeted Allele Detail

Summary

• Symbol: Crocc^tm1Tili
• Name: ciliary rootlet coiled-coil, rootletin; targeted mutation 1, Tiansen Li
• MGI ID: MGI:3580447
• Gene: Crocc Location: Chr4:140743948-140787861 bp, - strand Genetic Position: Chr4, 73.31 cM
• Alliance: Crocc^tm1Tili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98885
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP flanked PGK-neo selection cassette and additional sequence was inserted downstream of exon 3. RT-PCR confirms the presence of a longer transcript than wild-type. Immunoblot failed to detect wild-type protein in mutants. (J:98885)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crocc Mutation: 72 strains or lines available

References

• Original: J:98885 Yang J, et al., The ciliary rootlet maintains long-term stability of sensory cilia. Mol Cell Biol. 2005 May;25(10):4129-37
• All: 3 reference(s)