Nsila2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Nsila2^C57BL/6J
• Name: novelty/stress induced locomotor activation 2; C57BL/6J
• MGI ID: MGI:3580562
• QTL: Nsila2 Location: unknown Genetic Position: Chr3, cM position of peak correlated region/allele: 27.73 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased locomotor activation in a novel environment compared to A/J. (J:98477)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98477

QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.

In the AcB/BcA RC population, a locus at 29.5 cM on mouse Chromosome 3 near D3Mit185 showed significant linkage to locomotor activation in a novel environment. This locus is designated Nsila2 (novelty/stress induced locomotor activation 2). The C57BL/6J-derived allele at Nsila2 is associated with increased novelty/stress induced activation of locomotor activity. A second locus with significant linkage to locomotor activation mapped to 64.1 cM near D3Mit110. The QTL interval spans 64.1 cM - 76.2 cM. This locus is designated Nsila3 (novelty/stress induced locomotor activation 3). The A/J-derived allele at Nsila3 is associated with increased novelty/stress induced activation of locomotor activity. A potential candidate gene mapping near Nsila3 is Hnl (63.7 cM).

References

• Original: J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• All: 1 reference(s)