Nsila6^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Nsila6^C57BL/6J
• Name: novelty/stress induced locomotor activation 6; C57BL/6J
• MGI ID: MGI:3580570
• QTL: Nsila6 Location: unknown Genetic Position: Chr8, cM position of peak correlated region/allele: 39.33 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased locomotor activation in a novel environment compared to A/J. (J:98477)
• Inheritance: Not Specified

Notes

Nsila6 shows interaction with Nsila5 on mouse Chromosome 6. Animals homozygous for C57BL/6J-derived alleles at both Nsila6 and Nsila5 exhibit the greatest locomotor activation in a novel environment.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98477

QTLs associated with novelty/stress-induced locomotor activation were mapped using a series of recombinant inbred (RI) and recombinant congenic (RC) strains derived from C57BL/6J and A/J progenitor strains. Progenitor strain C57BL/6J exhibits greater activation of locomotor activity when placed in a novel open field environment compared to progenitor strain A/J. 1159 animals from the AXB/BXA RI series were genotyped with a panel of 780 polymorphic markers. 13 AcB and 31 BcA RC strains were genotyped witha panel of 625 polymorphic markers.

In the AXB/BXA RI population, a locus at 37 cM on mouse Chromosome 8 near D8Mit305 (LOD=3.84) showed significant linkage to locomotor activation in a novel environment. The interval between D8Mit132 (33 cM) and D8Mit305 (37 cM) showed maximum linkage (LOD=4.1) to the phenotype. This locus is designated Nsila6 (novelty/stress induced locomotor activation 6). The C57BL/6J-derived allele at Nsila6 is associated with increased novelty/stress induced activation of locomotor activity. Nsila6 shows interaction with a locus on mouse Chromosome 6 at 3.3 cM near D6Mit50, which is most likely the same locus as Nsila5. Animals homozygous for C57BL/6J-derived alleles at both Nsila6 and Nsila5 exhibit the greatest locomotor activation in a novel environment.

In the AcB/BcA RC population, a locus at 59 cM on mouse Chromosome 8 near D8Mit186 showed significant linkage to locomotor activation in a novel environment. The QTL interval spans 47 cM - 73 cM. This locus is designated Nsila7 (novelty/stress induced locomotor activation 7). The A/J-derived allele at Nsila7 is associated with increased novelty/stress induced activation of locomotor activity. A previously identified stress-related QTL mapping near Nsila7 is Siafq1 (56 cM).

References

• Original: J:98477 Gill KJ, et al., Quantitative trait loci for novelty/stress-induced locomotor activation in recombinant inbred (RI) and recombinant congenic (RC) strains of mice. Behav Brain Res. 2005 Jun 3;161(1):113-24
• All: 1 reference(s)