Crhr1taq3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Crhr1taq3^DBA/2J
• Name: Crhr1 transcript abundance QTL 3; DBA/2J
• MGI ID: MGI:3580622
• QTL: Crhr1taq3 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:98292

QTLs linked to the trans regulation of genes involved in the corticotropin-releasing factor system were mapped using male animals from 28 BXD recombinant inbred lines (B=C57BL/6J; D=DBA/2J). Transcript abundance of Crh, Crhr1, Crhbp, and Avp were used asquantitative traits. Parental strain DBA/2J exhibits lower transcript abundance of all 4 genes compared to parental strain C57BL/6J. A panel of 975 polymorphic loci was used for linkage analysis.

Significant linkage to Crhr1 expression mapped to 30 cM mouse Chromosome X. This locus is named Crhr1taq3 (Crhr1 transcript abundance QTL 3), and the 95% confidence interval of Crhr1taq3 spans 21 cM. A potential candidate gene mapping near Crhr1taq is Avpr2 at 29.5 cM.

References

• Original: J:98292 Garlow SJ, et al., Genetic analysis of the hypothalamic corticotropin-releasing factor system. Endocrinology. 2005 May;146(5):2362-8
• All: 1 reference(s)