Syngap1^tm1Grnt
Targeted Allele Detail

Summary

• Symbol: Syngap1^tm1Grnt
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1, Seth G N Grant
• MGI ID: MGI:3580631
• Synonyms: SynGAP^-
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^tm1Grnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98903
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exons encoding the C2 and GAP domains were replaced with a vector containing an IRES-lacZ-pA and a MC1-neo-pa cassette. Immunoblot demonstrated mutants had decreased levels of protein. (J:98903)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 49 strains or lines available

References

• Original: J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
• All: 7 reference(s)