Hras^tm1Grnt
Targeted Allele Detail

Summary

• Symbol: Hras^tm1Grnt
• Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Seth G N Grant
• MGI ID: MGI:3580632
• Synonyms: H-Ras^-
• Gene: Hras Location: Chr7:140770839-140773938 bp, - strand Genetic Position: Chr7, 86.48 cM
• Alliance: Hras^tm1Grnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98903
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a TAG3-IRES-Betageo-pa with stop codons in all reading frames into exon 4. Immunoblot demonstrated absence of protein in mutants. (J:98903)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hras Mutation: 30 strains or lines available

References

• Original: J:98903 Komiyama NH, et al., SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci. 2002 Nov 15;22(22):9721-32
• All: 1 reference(s)