Plag1^tm1Wjmv
Targeted Allele Detail

Summary

• Symbol: Plag1^tm1Wjmv
• Name: pleiomorphic adenoma gene 1; targeted mutation 1, Wim J M Van de Ven
• MGI ID: MGI:3580633
• Synonyms: Plag1^-
• Gene: Plag1 Location: Chr4:3900996-3938423 bp, - strand Genetic Position: Chr4, 2.18 cM, cytoband A1
• Alliance: Plag1^tm1Wjmv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96846
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A lacZ reporter gene fused in frame to the initiation codon and a PGK-neo selection cassette replaced the complete ORF. RT-PCR confirmed the complete absence of transcript in null mice. (J:96846)

Expression

In Mice Carrying this Mutation:	35 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plag1 Mutation: 32 strains or lines available

References

• Original: J:96846 Hensen K, et al., Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility. Dev Growth Differ. 2004 Oct;46(5):459-70
• All: 8 reference(s)