Tssk6^tm1Grj
Targeted Allele Detail

Summary

• Symbol: Tssk6^tm1Grj
• Name: testis-specific serine kinase 6; targeted mutation 1, Gibbes R Johnson
• MGI ID: MGI:3580646
• Synonyms: SSTK^-
• Gene: Tssk6 Location: Chr8:70354834-70356168 bp, + strand Genetic Position: Chr8, 34.05 cM, cytoband C1
• Alliance: Tssk6^tm1Grj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98891
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a floxed neo selection cassette. RT-PCR failed to detect transcript in testicular samples from mutant mice. Immunohistochemistry and in situ hybridization analyses also confirmed absence of expression. (J:98891)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tssk6^tm1Grj/Tssk6^tm1Grj	involves: 129 * C57BL/6
ht2	Tssk6^tm1Grj/Tssk6^+	involves: 129 * C57BL/6

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms Sex:
cellular	√	√
oligozoospermia	√	√
abnormal sperm head morphology	√
asthenozoospermia	√
reproductive system	√	√
asthenozoospermia	√
abnormal spermatogenesis	√
oligozoospermia	√	√
abnormal sperm head morphology	√
male infertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tssk6 Mutation: 5 strains or lines available

References

• Original: J:98891 Spiridonov NA, et al., Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61
• All: 3 reference(s)