Cox4i2^tm1Hutt
Targeted Allele Detail

Summary

• Symbol: Cox4i2^tm1Hutt
• Name: cytochrome c oxidase subunit 4I2; targeted mutation 1, Maik Huttemann
• MGI ID: MGI:3580677
• Gene: Cox4i2 Location: Chr2:152596093-152606957 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Cox4i2^tm1Hutt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187640
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of transcripts in homozygous mice. Western blot analysis confirmed the absence of protein expression in lungs from homozygous mice. (J:187640)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cox4i2 Mutation: 13 strains or lines available

References

• Original: J:187640 Huttemann M, et al., Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 2012 Sep;26(9):3916-30
• All: 5 reference(s)