Cox7a1^tm1Hutt
Targeted Allele Detail

Summary

• Symbol: Cox7a1^tm1Hutt
• Name: cytochrome c oxidase subunit 7A1; targeted mutation 1, Maik Huttemann
• MGI ID: MGI:3580679
• Gene: Cox7a1 Location: Chr7:29883596-29885455 bp, + strand Genetic Position: Chr7, 17.31 cM
• Alliance: Cox7a1^tm1Hutt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192141
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All three exons were replaced with a neo cassette. QRT-PCR confirmed the absence of transcript expression. (J:192141)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cox7a1 Mutation: 7 strains or lines available

References

• Original: J:192141 Huttemann M, et al., Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy. Mitochondrion. 2012 Mar;12(2):294-304
• All: 3 reference(s)