Tg(Myh6-GFP,MAP2K6)8Ywa
Transgene Detail

Summary

• Symbol: Tg(Myh6-GFP,MAP2K6)8Ywa
• Name: transgene insertion 8, Yibin Wang
• MGI ID: MGI:3581034
• Synonyms: MHC-flox-MKK6bE
• Transgene: Tg(Myh6-GFP,MAP2K6)8Ywa Location: unknown
• Alliance: Tg(Myh6-GFP,MAP2K6)8Ywa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-GFP,MAP2K6)8Ywa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAP2K6 (5608)

  Map2k6

  (MGI:1346870)

• Mutation details: This transgene contain murine alpha-myosin heavy chain promoter driving GFP minigene flanked by two loxP sites, followed by another minigene coding for a constructively active mutant form of human MAP2K6. In absence of cre recombinase, only GFP is expressed. When cre recombinase is expressed in the cell hovering this transgene, DNA recombination events between the two loxP sites resulted in the deletion f the GFP minigene sequences, and the expression of MAP2K6 minigene. (J:72242)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:72242 Liao P, et al., The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12283-8
• All: 2 reference(s)