Cplaq8^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cplaq8^DBA/2J
• Name: circadian period of locomotor activity 8; DBA/2J
• MGI ID: MGI:3581256
• QTL: Cplaq8 Location: Chr3:7586174-7956698 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 2.01 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased circadian locomotor activity compared to C57BL/6J. (J:92583)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:92583

A locus on mouse Chromosome 3 shows association with longer circadian rhythm in a congenic strain carrying the Car2 null mutation. The B6.D2-Car2ⁿ/J congenic carries a DBA/2J-derived Car2ⁿ region of mouse Chromosome 3 between D3Mit60 (0 cM) and D3Mit221 (2.4 cM) on a C57BL/6J genetic background. Two different recombinant inbred strains named R1 and R2 were created from B6.D2-Car2ⁿ/J. The recombinant congenic R1 carries DBA/2J-derived DNA from D3Mit164 (2.4 cM) to D3Mit221 (2.4 cM) on a C57BL/6J genetic background. The recombinant congenic R2 carries DBA/2J-derived DNA from D3Mit60 (0 cM) to D3Mit149 (2.4) on a C57BL/6J genetic background.

The R1 line exhibits increased circadian rhythm compared to the R2 line and C57BL/6J control animals. This finding suggests that a QTL for circadian rhythm is localized to a 1 cM interval on mouse Chromosome 3 encompassing D3Mit164 and D3Mit221. This locus is named Cplaq8 (circadian period of locomotor activity 8). An allele assay showed that Car2 is located within this interval and it is considered a candidate gene for Cplaq8.

References

• Original: J:92583 Kernek KL, et al., A locus for circadian period of locomotor activity on mouse proximal chromosome 3. Chronobiol Int. 2004 May;21(3):343-52
• All: 1 reference(s)