Tlag2^C57L/J
QTL Variant Detail

Summary

• QTL variant: Tlag2^C57L/J
• Name: T lymphoma attenuation gene 2; C57L/J
• MGI ID: MGI:3581260
• QTL: Tlag2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C57L/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This locus confers susceptibility to MNU-induced lymphomas compared to AKR/J. (J:74369)
• Inheritance: Dominant

Notes

Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR/J-derived alleles at Tlag1 and heterozygous for AKR/J- and C57L/J-derived alleles at Tlag2 exhibit the greatest susceptibility to MNU-induced lymphomas.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:74369

Tlag2, a gene responsible for MNU-induced lymphoma susceptibility, was mapped to 53 cM on mouse Chromosome 4 in a AKR/J x (AKR/J x C57L/J)F1 backcross and confirmed in F2 and F3 animals. (Animals fixed for AKR/J-derived alleles at Tlag1 on mouse Chromosome 7 were used in the study.) Peak lymphoma susceptibility is associated with marker Pmv19 at 52.7 cM with the C57L/J-derived allele conferring dominant lymphoma susceptibility. Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR-derived alleles at Tlag1 and heterozygous at Tlag2 exhibited the highest incidence of MNU-induced tumors. Several candidate genes mapping near Tlag2 are Cdkn2a, Cdkn2b, Lyr, Pcts, Tie1, Tek, Mycl1, Jun, Lck, Pctr1, Pctr2, and Tal1.

References

• Original: J:74369 Angel JM, et al., Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002 Feb;33(2):105-12
• All: 1 reference(s)